Jens Staal

The paper introduces genetically encoded FRET sensors to detect protease activities in plants, demonstrating their use in monitoring metacaspase and Tobacco Etch Virus protease in vivo.

This study genetically engineers a probiotic yeast to produce abscisic acid (ABA) in the gut, but finds low serum ABA levels due to temperature-dependent production challenges.

The paper characterizes auto-inhibition mechanisms in CARD-CC proteins by generating chimeric CARD9 constructs and identifying activating mutations linked to diseases.

The paper designs a smaller plasmid vector by optimizing resistance markers and promoter regions, achieving a 24% size reduction.

The paper identifies synergistic PKC/CARD-CC combinations and heterodimerization effects using CRISPR/Cas9 and reporter gene assays.