Rudi Beyaert

This study shows that CREB knockout in Foxp3+ Tregs increases IL-10 and ST-2 expression, enhancing their suppressive function and preventing gut inflammation.

This study genetically engineers a probiotic yeast to produce abscisic acid (ABA) in the gut, but finds low serum ABA levels due to temperature-dependent production challenges.

This study shows that IKK signaling in T cells protects against RIPK1-dependent cell death by phosphorylating RIPK1 and inducing A20, which modulates RIPK1 function.

The paper characterizes auto-inhibition mechanisms in CARD-CC proteins by generating chimeric CARD9 constructs and identifying activating mutations linked to diseases.

The paper designs a smaller plasmid vector by optimizing resistance markers and promoter regions, achieving a 24% size reduction.

The paper identifies synergistic PKC/CARD-CC combinations and heterodimerization effects using CRISPR/Cas9 and reporter gene assays.