Paul B. S. Clarke

This study shows that Brd4 is recruited to chromatin by cAMP/PKA signaling in response to D1R activation in striatal neurons, regulating gene expression and affecting downstream signaling pathways.

The paper uses single-cell FRET imaging to analyze drug-induced signaling responses in rat neurons, revealing significant intercellular variation not detectable by bulk methods.

This study uses fiber photometry with FRET biosensors to show that D1R signaling is sensitized in Parkinsonian rats but becomes desensitized with L-DOPA treatment, leading to increased dyskinesia.