Terence E. Hébert

Gαq-stimulated gene expression is insensitive to Bromo extra terminal domain inhibitors in HEK 293 cells

The paper tests BET protein responsiveness to G protein isoforms in HEK 293 cells and finds Gq-induced gene expression is insensitive to BET inhibitors, while Gs-induced expression is sensitive to BET degradation.

The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization

This study shows that loss of GPR52 in breast cancer cells increases cell clustering, EMT features, and tumor burden in zebrafish, suggesting GPR52 as a potential therapeutic target.

Spt5 C-terminal repeat domain phosphorylation and length negatively regulate heterochromatin through distinct mechanisms

This study shows that Spt5 CTD phosphorylation and length regulate heterochromatin formation through distinct mechanisms in S. pombe.

Dopamine D1 receptor activation and cAMP/PKA signalling mediate Brd4 recruitment to chromatin to regulate gene expression in rat striatal neurons

This study shows that Brd4 is recruited to chromatin by cAMP/PKA signaling in response to D1R activation in striatal neurons, regulating gene expression and affecting downstream signaling pathways.

Single cell analysis of population-wide nuclear and cytosolic drug responses using high-content FRET imaging: measuring protein kinase activation in rat primary striatal neurons

The paper uses single-cell FRET imaging to analyze drug-induced signaling responses in rat neurons, revealing significant intercellular variation not detectable by bulk methods.

Dopamine D1 receptor signalling in dyskinetic Parkinsonian rats revealed by fiber photometry using FRET-based biosensors

This study uses fiber photometry with FRET biosensors to show that D1R signaling is sensitized in Parkinsonian rats but becomes desensitized with L-DOPA treatment, leading to increased dyskinesia.

Differential activation of P-TEFb complexes in the development of cardiomyocyte hypertrophy following activation of distinct GPCRs

The paper investigates how different GPCRs regulate P-TEFb complexes in cardiomyocyte hypertrophy, showing distinct roles for SEC and Brd4 in response to 1-AR and ETR activation.