Jason C. Tanny

The paper tests BET protein responsiveness to G protein isoforms in HEK 293 cells and finds Gq-induced gene expression is insensitive to BET inhibitors, while Gs-induced expression is sensitive to BET degradation.

The paper identifies a gene regulatory function of the Rtf1-H2Bub1-H3K4me axis and Rpb1 CTD in controlling fungal drug tolerance by linking them to resistance against hydroxyurea and azole antifungals.

This study shows that Spt5 CTD phosphorylation and length regulate heterochromatin formation through distinct mechanisms in S. pombe.

This study shows that Brd4 is recruited to chromatin by cAMP/PKA signaling in response to D1R activation in striatal neurons, regulating gene expression and affecting downstream signaling pathways.

The paper uses single-cell FRET imaging to analyze drug-induced signaling responses in rat neurons, revealing significant intercellular variation not detectable by bulk methods.

This study uses fiber photometry with FRET biosensors to show that D1R signaling is sensitized in Parkinsonian rats but becomes desensitized with L-DOPA treatment, leading to increased dyskinesia.

This study investigates how Spt5 phosphorylation and the Rtf1 Plus3 domain regulate RNAPII elongation in fission yeast through distinct mechanisms.

The paper investigates how different GPCRs regulate P-TEFb complexes in cardiomyocyte hypertrophy, showing distinct roles for SEC and Brd4 in response to 1-AR and ETR activation.

The paper identifies a Cdk9-PP1 kinase-phosphatase switch that regulates the transition of RNA polymerase II from elongation to termination by modulating Spt5 phosphorylation.

The paper investigates the interaction between Cdk9, H2Bub1, and the Clr6-CII HDAC complex in regulating antisense and sense transcription in fission yeast.

The paper shows that histone H2B ubiquitylation regulates histone gene expression in fission yeast by affecting transcription elongation and cell cycle progression.