A One-Step Chemoselective Strategy for Hydroxymethylcytosine Sequencing in DNA and RNA
Jiahao Li, Peihong Zhang, Arvin Yanchu Wang, Yuhao Zhong, Yiding Wang, Ruitu Lyu, Chenyou Zhu, Qing Dai, Chuan He
This paper introduces BALT-seq, a one-step chemoselective method for hydroxymethylcytosine profiling in DNA and RNA, showing high concordance with existing methods and improved RNA enrichment.
bioRxiv · Sep 17, 2026 · PreprintGenomics