William Guy Fairbrother

The paper shows that accumulation of intracellular RNA lariats in DBR1-null cells reduces antiviral response by desensitizing dsRNA sensors.

The paper identifies splice-disrupting mutations in hotspot exons and shows that antisense oligonucleotides (ASOs) can revert splicing defects in these exons.

The paper identifies splicing variants in modern and archaic humans using functional assays and shows differences in purifying selection and adaptive introgression.

The paper introduces MMSplice, a modular framework for predicting genetic variant effects on splicing, achieving performance comparable to state-of-the-art methods.