Glaucius Oliva

This study identifies semicarbazone and thiosemicarbazone analogs as competitive inhibitors of SARS-CoV-2 Mpro through virtual screening and biochemical validation.

The paper identifies fragment binders and mutationally intolerant sites in Zika virus NS2B-NS3 protease to develop resistance-resilient antiviral inhibitors.

This study uses high-throughput crystallographic fragment screening to identify 46 fragment binding poses on ZIKV NS3Hel, providing templates for antiviral drug design.