Author

R. Blake Richardson

Icahn School of Medicine at Mount Sinai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Matthew J. EvansiD· 4 shared Eva BednarskiiD· 3 shared Jean K. LimiD· 3 shared Anna I. Hermacinski· 2 shared Caroline KikawaiD· 2 shared Jesse D. BloomiD· 2 shared Adolfo García‐SastreiD· 1 shared Alison W. AshbrookiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersMicrobiology

Matthew J. EvansORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Coevolutionary constraints of Zika virus nonstructural protein 5 replication and interferon antagonism activities

R. Blake Richardson, Caroline Kikawa, Amit Garg, Eva Bednarski, Madihah S. Salim, David J. Bacsik, Ethan C. Veit, Anna I. Hermacinski, Rachael E. Hamilton, Adolfo García‐Sastre, Jesse D. Bloom, Jean K. Lim, Matthew J. Evans

This study identifies evolutionary constraints linking Zika virus NS5 replication and interferon antagonism by analyzing fitness landscapes and attenuation in mice.

Nature Communications · Oct 28, 2026Peer-reviewedMicrobiology

The Hao-Fountain syndrome gene USP7 restricts neurotropic orthoflavivirus entry through cell intrinsic control of endosomal dynamics

Boris Bonaventure, Kyna Reyes, Marie France Martin, Heng Pan, R. Blake Richardson, Eva Bednarski, Alison W. Ashbrook, Allison Sowa, William G.M. Janssen, Oded Danziger, Anastasija Čupić, Lisa Miorin, Charles M. Rice, Jean K. Lim, Brad R. Rosenberg, , Jeffrey R. Johnson

This study identifies USP7 as a gene that restricts neurotropic orthoflavivirus entry by controlling endosomal dynamics, with mutations in USP7 increasing susceptibility to ZIKV infection.

bioRxiv · Sep 10, 2026 · PreprintMicrobiology

Construction of a CMV promoter-driven Langat virus cDNA clone and reporter viruses

Anna I. Hermacinski, R. Blake Richardson, Eva Bednarski, Madihah Salim, Amit Kumar Garg, Jean K. Lim, Matthew J. Evans

The paper constructs a CMV promoter-driven Langat virus cDNA clone and reporter viruses for studying replication, gene function, and pathogenesis.

bioRxiv · Nov 13, 2025 · PreprintMicrobiology

Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors

Xiaomin Ni, R. Blake Richardson, Andre Schutzer Godoy, Matteo Paolo Ferla, Caroline Kikawa, Jenke Scheen, William W. Hannon, Eda Çapkın, Noa Lahav, Blake H. Balcomb, Peter George Marples, M. Fairhead, Si-Yi Wang, Eleanor Williams, Charles W.E. Tomlinson, , F. von Delft

The paper identifies fragment binders and mutationally intolerant sites in Zika virus NS2B-NS3 protease to develop resistance-resilient antiviral inhibitors.

Nature Communications · Oct 8, 2025Peer-reviewedBiochemistry