Boris Halgand

This paper compares transcriptomic and functional differences between healthy and degenerated ovine intervertebral disc cells, finding age-related inflammatory and senescence signatures and shared transcriptional modules with human degenerated discs.

This paper develops a 3D in vitro model of an ovine intervertebral disc using a PCL frame and alginate hydrogel, demonstrating effective cell alignment and phenotype preservation.

This study develops covalent alginate hydrogels using SPAAC cross-linking for encapsulating human adipose MSCs, demonstrating their viability and immunomodulatory activity in vitro.