BiochemistryAngewandte Chemie International EditionPeer-reviewed
Promotion of RNF168-Mediated Nucleosomal H2A Ubiquitylation by Structurally-defined K63-Polyubiquitylated Linker Histone H1
Qiang Shi, Zhiheng Deng, Liying Zhang…·Lei Liu
This study develops a chemical synthesis method to create polyubiquitylated linker histone H1.0, revealing its role in enhancing RNF168-mediated H2A ubiquitylation through structural and biochemical analysis.
22 citations