Zebin Tong

This study identifies steric compatibility between BIRC6 and UBA6 as the mechanism enabling specific activation of BIRC6 by UBA6 over UBA1.

The paper identifies a unique mechanism by which ASXL1 K351 monoubiquitination enhances PR-DUB activity through structural stabilization, enabling efficient H2AK119Ub deubiquitination.

This study develops a chemical synthesis method to create polyubiquitylated linker histone H1.0, revealing its role in enhancing RNF168-mediated H2A ubiquitylation through structural and biochemical analysis.

This study identifies a unique mechanism by which SSX1 recognizes H2AK119Ub nucleosomes through a cryptic groove, enabling specific hijacking of the BAF complex in synovial sarcoma.

This study determines the cryo-EM structures of RNF168/UbcH5c-Ub/nucleosome complexes to elucidate the mechanism of H2A K13/K15 site-specific ubiquitination.