Promotion of RNF168-Mediated Nucleosomal H2A Ubiquitylation by Structurally-defined K63-Polyubiquitylated Linker Histone H1
Qiang Shi, Zhiheng Deng, Liying Zhang, Zebin Tong, Jiabin Li, Guo‐Chao Chu, Huasong Ai, Lei Liu
This study develops a chemical synthesis method to create polyubiquitylated linker histone H1.0, revealing its role in enhancing RNF168-mediated H2A ubiquitylation through structural and biochemical analysis.
Angewandte Chemie International Edition · Oct 4, 2024Peer-reviewedBiochemistry