Author

Kezhang He

Tsinghua UniversityORCID 0000-0003-3107-7302Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Pengqi WangiD· 2 shared Qiaomei Xue· 2 shared Sheng DingiD· 2 shared Tianhua MaiD· 2 shared Bowen WangiD· 1 shared Bowen WangiD· 1 shared Dan WangiD· 1 shared Dan WangiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCancer Biology

Pengqi WangORCID

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Author profile →

3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 10, 2025

Pharmacological Induction of Irreversible Senescence in Drug-Tolerant Persister Cells Prevents Tumor Relapse

Bowen Wang, Yun Zhi, Pengqi Wang…·Sheng Ding

This paper identifies a drug combination that irreversibly senesces drug-tolerant persister cells, preventing tumor relapse in melanoma models.

DOI 10.1101/2025.10.10.681532

mouseexperimental assay

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Cancer BiologybioRxivPreprintNov 1, 2024

Reinforced identity confers cells with cancer hallmarks

Haixia Yang, Pengqi Wang, Pengcheng Tan…·Sheng Ding

This study identifies reinforced cell identity as a driver of cancer development and demonstrates a drug targeting this identity in AML.

DOI 10.1101/2024.11.01.621626

humanbulk RNA-seq

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Molecular BiologyNature Structural & Molecular BiologyPeer-reviewedJan 4, 2024

Synovial Sarcoma X Breakpoint 1 Protein uses a cryptic groove to selectively recognize H2AK119Ub Nucleosomes

Zebin Tong, Huasong Ai, Ziyu Xu…·Lei Liu

This study identifies a unique mechanism by which SSX1 recognizes H2AK119Ub nucleosomes through a cryptic groove, enabling specific hijacking of the BAF complex in synovial sarcoma.

41 citationstop 2%

humanproteomics

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