Luis Francisco Hernández Sánchez

This study extends protein interaction networks by incorporating small molecules, protein isoforms, and post-translational modifications to better represent biological systems.

PathwayMatcher maps omics data to pathway networks considering protein isoforms and modifications, enabling more precise pathway analysis.

The paper introduces PEFF, a new format for proteomics data that enhances FASTA with metadata for sequence variants and PTMs, enabling better analysis in proteogenomics and top-down proteomics.

This study examines the structure of pathway knowledgebases like Reactome and its impact on interpreting biomedical datasets, aiming to improve user understanding and result reliability.