Mechanisms Governing Target Search and Binding Dynamics of Hypoxia-Inducible Factors
Yu Chen, Claudia Cattoglio, Gina M. Dailey, Qiulin Zhu, Robert Tjian, Xavier Darzacq
The paper investigates how HIF-1 and HIF-2 subunits exhibit distinct binding dynamics and gene regulation despite sharing the same DNA binding specificity, revealing the role of intrinsically disordered regions in chromatin binding and target selectivity.
eLife · Nov 2, 2022Peer-reviewedMolecular Biology