Molecular BiologybioRxivPreprint
Identification of post-transcriptional modifications in nucleic acid sequences using purpose-designed molecular beacons
Parul Sahu, Getulio Pereira, Jian Wang…·Ionita Calin Ghiran
The paper introduces a method using molecular beacons to directly detect miRNAs and isomiRs in cells and extracellular vesicles without RNA isolation, leveraging electrophoretic mobility and computational design for m6A modifications.
DOI 10.1101/2023.05.25.542360