Ionita Calin Ghiran

This study optimizes nanoFACS for sorting and analyzing extracellular vesicles using the CytoFLEX SRT, demonstrating its utility in isolating nanoparticles and detecting miRNA in biofluids.

The paper identifies extracellular vesicles (sEVs) from EBV-transformed B-cells as a vehicle for exporting host DNA and EBV EBER1 RNA, linking peripheral EBV infection to distal tissue signaling in MS.

This study investigates the effects of isoquercetin on sickled red blood cells in mice, showing increased elongation and dehydration when thiol isomerases are antagonized.

The paper develops RPSPASS, a software tool for automated analysis of microfluidic nanoparticle data, improving accuracy, ergonomics, and reporting transparency.

This study shows cannabinoids reduce m6A methylation in miRNAs of SIV-infected macaques, shifting their profile towards an anti-inflammatory state.

The paper introduces a method using molecular beacons to directly detect miRNAs and isomiRs in cells and extracellular vesicles without RNA isolation, leveraging electrophoretic mobility and computational design for m6A modifications.

The paper designs a bifunctional AND-gate ligand to modulate cell-cell interactions by avoiding thrombosis and RBC adhesion.

This study evaluates the accuracy, reproducibility, and bias of small RNA-seq across five protocols and nine labs, finding protocol-specific bias that can be mitigated with adapters and computational corrections.