Scott T. Quarmby

This paper introduces RaPiD-mAb-MS, a direct infusion mass spectrometry method for rapid peptide mapping of monoclonal antibodies, achieving 100-fold faster analysis with high sequence coverage and comparable results to conventional methods.

The paper investigates how emitter positioning affects peptide signal intensity in nanoflow electrospray ionization for proteomics, finding consistent signal behavior across m/z range.

This paper evaluates six plasma proteomic technologies, finding that Seer Proteograph XT provides the highest proteomic depth and quantification, while Olink Explore HT shows comparable LOD but worse LOQ.

The paper develops SPE-CZE-MS for quantifying phosphorylated peptides in single-cell equivalent phosphoproteomics, demonstrating improved sensitivity and compatibility with mass spectrometry.