Shihong Chen

The paper constructs a synthetic disomic yeast using SCRaMbLE and a newly synthesized chromosome to study aneuploidy phenotypes, finding that both copy number and specific chromosomal regions affect fitness.

This paper introduces a DNA-based data archiving system called Yin-Yang Codec, which achieves high recovery rates and physical information density in both in vitro and in vivo storage.

Chamaeleo provides a library for DNA storage coding schemes, offering flexibility and expandability over existing single-scheme implementations.