This study uses spatial proteomics to reveal that TP53 mutant AML residual disease forms immunosuppressive niches in the bone marrow, segregated from T-cells, suggesting niche-level immune evasion.

bioRxiv · May 19, 2026 · PreprintCancer Biology

Macrophage-Dendritic Cell-T-Cell Tetrads Orchestrate Antitumor Immunity and Response to Checkpoint Blockade

Mehdi Chaib, Muhammad Aminu, Shelley M. Herbrich, Mahshid Arabi, Yue Xuan, Akshay Basi, Tod D. Casasent, Marc Daniel Macaluso, Kenneth H. Hu, Matthew M. Gubin, Xi Chen, James J. Mancuso, Sreyashi Basu, Sonali Jindal, Jared Burks, , Padmanee Sharma

The paper identifies tetrads as a multicellular immune unit that correlates with antitumor immunity and response to checkpoint blockade in mouse and human tumors.

bioRxiv · Dec 29, 2025 · PreprintImmunology

Multimodal Spatial Proteomic Profiling in Acute Myeloid Leukemia

Christopher P. Ly, Ivo Veletić, Christopher D. Pacheco, Enes Dasdemir, Fatima Zahra Jelloul, Sammy Ferri Borgogno, Akshay Basi, Javier A. Gomez, Jessica Lynn Root, Patrick Kevin Reville, Sonali Jindal, Sreyashi Basu, Padmanee Sharma, Andres Ernesto Quesada, Carlos Bueso-Ramos, , Hussein A. Abbas

This study uses high-plex spatial proteomics to identify tertiary lymphoid-like structures in AML bone marrow and links them to patient outcomes.

npj Precision Oncology · May 20, 2025Peer-reviewedCancer Biology

Integrated single cell spatial multi-omics landscape of WHO grades 2-4 diffuse gliomas identifies locoregional metabolomic regulators of glioma growth

Yanxia Ma, Shamini Ayyadhury, Sanjay Kumar Singh, Yashu Vashishath, Cagri Ozdemir, Trevor D. McKee, N. Rich Nguyen, Akshay Basi, Duncan H. F. Mak, Javier A. Gomez, Jason T. Huse, Sana Noor, Daniel E. Winkowski, Regan Baird, Jeffrey S. Weinberg, , Chibawanye Ene

The paper integrates spatial multi-omics data from diffuse gliomas to identify locoregional metabolomic regulators linked to glioma growth and treatment resistance.

bioRxiv · Apr 30, 2025 · PreprintCancer Biology