Niche-level immune evasion in TP53 mutant AML residual disease revealed by spatial proteomics
Mizuno Hideaki, Yuki Nishida, Andrea D. Bedoy, Edward Ayoub, Yoonkyu Lee, Akshay Basi, Koji Sasaki, Guillermo Garcia‐Manero, Jared Burks, Rashmi Kanagal‐Shamanna, Michael Andreeff
This study uses spatial proteomics to reveal that TP53 mutant AML residual disease forms immunosuppressive niches in the bone marrow, segregated from T-cells, suggesting niche-level immune evasion.
bioRxiv · May 19, 2026 · PreprintCancer Biology