Pharmacology & ToxicologybioRxivPreprint
Fine-tuning an intracellular allosteric pocket programs GPCR signaling bias
Xinchao Shi, Ruidi Zhu, Kewei CHANG…·Jian Zhang
This study fine-tunes an intracellular allosteric pocket of NTSR1 to program GPCR signaling bias, revealing how ligand modifications alter transducer coupling and downstream signaling.
DOI 10.64898/2026.10.22.760766