Author

Mingzhu Zhao

Shanghai Jiao Tong University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Genomics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Assay:proteomics· 3 Approach:deep learning· 2 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jian ZhangiD· 2 shared Jixiao HeiD· 2 shared Xun LuiD· 2 shared Arong Li· 1 shared Bin LiaoiD· 1 shared Chuanqiao DongiD· 1 shared Chunhao Zhu· 1 shared Chunyu Sun· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersPharmacology & Toxicology

Jian ZhangORCID

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Author profile →

4 papers

Recent·Most cited

Fine-tuning an intracellular allosteric pocket programs GPCR signaling bias

Xinchao Shi, Ruidi Zhu, Kewei CHANG, Peng Yu, Qingning Yuan, 张云云, Xun Lu, Ziwei Zhou, Chunhao Zhu, Xiaobing Lan, Mingyu Li, Rui Li, Xin Qiao, Weidi Xie, Youwen Zhuang, , Jian Zhang

This study fine-tunes an intracellular allosteric pocket of NTSR1 to program GPCR signaling bias, revealing how ligand modifications alter transducer coupling and downstream signaling.

bioRxiv · Oct 27, 2026 · PreprintPharmacology & Toxicology

Chemi-Proteome Language Attention Network Empowers Fragment-Based Ligand Interactome and Binding Sites Discovery with Evidence

Bin Liao, Jixiao He, Mingzhu Zhao, Xiaozhen Cui, Cui Yunxia, Chuanqiao Dong, Hongyan Sun, Liang Zhang, Jian Zhang

C-PLANK improves ligand-protein interaction prediction by integrating cellular context and fragment-based chemoproteomics data, outperforming existing methods and identifying novel ligands.

bioRxiv · Aug 30, 2026 · PreprintBioinformatics

Electron-density informed effective and reliable de novo molecular design and lead optimization with ED2Mol

Mingyu Kenneth Li, Kun Song, Mingzhu Zhao, Gengshu You, Jie Zhong, Mengxi Zhao, Arong Li, Yu Chen, Guobin Li, Ying Kong, Jiacheng Wei, Zhaofu Wang, Jiamin Zhou, Hongbing Yang, Shichao Ma, , Jian Zhang

ED2Mol improves de novo molecular design and lead optimization by incorporating electron density information, achieving high physical reliability and success rates in generating bioactive compounds.

bioRxiv · Dec 18, 2024 · PreprintBioinformatics

Structural variation, functional differentiation and expression characteristics of the AP2/ERF gene family and its response to cold stress and methyl jasmonate in Panax ginseng C.A. Meyer

Jing Chen, Yuanhang Zhou, Qi Zhang, Qian Liu, Li Li, Chunyu Sun, Kangyu Wang, Yanfang Wang, Mingzhu Zhao, Hongjie Li, Yilai Han, Ping Chen, Ruiqi Li, Jun Lei, Meiping Zhang, Yi Wang

This study identifies and characterizes the AP2/ERF gene family in ginseng, showing functional differentiation and responses to cold stress and methyl jasmonate.

PLoS ONE · Mar 16, 2020Peer-reviewedGenomics