Mingyu Kenneth Li

DASH samples function-related metastable states of proteins, revealing new folding states and allosteric sites, verified by experiments and crystal structures.

The paper introduces an automated workflow for high-throughput assembly of large DNA libraries using yeast-based methods, achieving high success rates in assembling diverse DNA constructs.

ED2Mol improves de novo molecular design and lead optimization by incorporating electron density information, achieving high physical reliability and success rates in generating bioactive compounds.

The paper synthesizes a shorter yeast chromosome and studies its fusion with other chromosomes, revealing new 3D structural interactions and Red1 binding patterns.