Emeline F. Nandrot

The paper uses iPSC-derived RPE cells to compare molecular differences between AMD with and without reticular pseudodrusen, identifying distinct pathways and genetic influences.

The paper identifies CD14 and TLR4 as co-receptors that regulate circadian retinal phagocytosis through interactions with SR-B2, CD36, and MerTK.

The paper shows that loss of IFT20 and IFT88 in RPE cells impairs phagocytosis and metabolism by affecting photoreceptor binding, membrane morphology, and mitochondrial function.

This study identifies metabolic impairments and oxidative stress in Prpf31 mutant mouse RPE cells as key factors in retinitis pigmentosa pathogenesis.