Wolfgang Weninger

This study identifies a conserved chromatin-driven maturation checkpoint in macrophages that occurs independently of tissue specialization and enhances innate immune responsiveness.

The paper constructs a scRNA-seq atlas of chronic inflammatory skin diseases by integrating datasets from 27 diseases, identifying shared and disease-specific inflammatory signatures.

This study identifies stiffness-dependent LOX regulation via HIF-1 in psoriasis, linking ECM modifications to disease progression through mechanosensitive fibroblasts.