Martin C. Simon

This study benchmarks H&E-based gene expression prediction methods in skin tissue, finding poor performance overall and limited utility for single-cell analysis.

The paper constructs a scRNA-seq atlas of chronic inflammatory skin diseases by integrating datasets from 27 diseases, identifying shared and disease-specific inflammatory signatures.

The paper shows that mitochondrial import stress causes neurodegeneration, which is opposed by PERK-eIF2α signaling, with PERK overexpression protecting against it.

The paper shows that two RDRs in Paramecium are required to convert exogenous dsRNA into siRNAs for RNAi, contrasting with known functions in other organisms.

This study compares nectar production mechanisms in monocot Ananas comosus and dicot Nicotiana tabacum using transcriptomic and metabolic analyses, revealing differences in sucrose transport and secretion.

The paper characterizes the epigenomic organization of the Paramecium macronuclear genome, revealing broad histone mark domains and unique transcriptional features.

The paper investigates the role of two Piwi proteins in transgene-induced silencing in Paramecium, showing they have distinct but overlapping functions in generating and processing siRNAs for chromatin-level gene silencing.

The paper identifies aging-associated differences in vesicle-bound and freely circulating small regulatory RNAs in mice, showing tRNA fragments and miRNAs strongly correlate with aging.

RAPID automates siRNA analysis by generating visualizations and reports, enabling comparison of datasets and differential expression analysis.