Hao Yuan

Building optimized single-cell reference atlases with scAtlasTb

The paper introduces scAtlasTb, a framework for building and optimizing single-cell reference atlases, demonstrating its application on three Human Cell Atlas projects.

A scRNA-seq atlas of chronic inflammatory skin diseases

The paper constructs a scRNA-seq atlas of chronic inflammatory skin diseases by integrating datasets from 27 diseases, identifying shared and disease-specific inflammatory signatures.

A single cell and spatial genomics atlas of human skin fibroblasts in health and disease

This study creates a spatial genomics atlas of human skin fibroblasts in health and disease, identifying six major populations and three disease-specific subtypes.

An atlas of TF driven gene programs across human cells

The paper creates a regulon atlas mapping TF activity across human cell types and uses it to link disease signatures to cell types and TFs, improving disease risk locus analysis.