Radojka M. Savić

This study reevaluates PaBQU and DBQU regimens in mouse models, finding they have lesional liability in complex lesions, which may explain their failure in a human trial.

The paper develops a predictive model to rank tuberculosis regimens by relapse prevention using 28-day CFU and RS ratio data from a relapsing mouse model.

This paper predicts the early bactericidal activity of tuberculosis drug combinations using a translational PK-PD modeling approach, showing consistent interaction patterns and reliable predictions for clinical outcomes.

Rabbit lesion microdissection and pharmacokinetic modeling show bedaquiline takes months to reach deep caseum and years to clear, while TBAJ-587 and TBAJ-876 shorten these windows.

The paper evaluates the effectiveness of standard TB drugs in mice, showing rifampin's critical role in killing bacteria and preventing resistance.