Jacqueline P. Ernest

Predicting early bactericidal activity of tuberculosis drug combinations using a translational pharmacokinetic-pharmacodynamic modeling approach

This paper predicts the early bactericidal activity of tuberculosis drug combinations using a translational PK-PD modeling approach, showing consistent interaction patterns and reliable predictions for clinical outcomes.

The kinetics of bedaquiline diffusion in tuberculous cavities opens a window for emergence of resistance.

Rabbit lesion microdissection and pharmacokinetic modeling show bedaquiline takes months to reach deep caseum and years to clear, while TBAJ-587 and TBAJ-876 shorten these windows.

Contribution of front-line, standard of care drugs to bactericidal responses, resistance emergence, and cure in murine models of easy- or hard-to-treat tuberculosis disease

The paper evaluates the effectiveness of standard TB drugs in mice, showing rifampin's critical role in killing bacteria and preventing resistance.