Author

Jan A. Schlegel

Dr. Margarete Fischer-Bosch-Institute of Clinical PharmacologyORCID 0000-0003-3159-8079Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Neuroscience· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexandra M. KleiniD· 1 shared Bartłomiej PorębskiiD· 1 shared Ben MurrelliD· 1 shared Bettina Vignolo· 1 shared Christoph ErbacheriD· 1 shared Christoph MaackiD· 1 shared Erdinç SezginiD· 1 shared Erhard Wischmeyer· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Alexandra M. KleinORCID

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3 papers

Recent·Most cited

IGFBPs define distinct pro-tumorigenic CAF subtypes in lung cancer tumour-microenvironment

Ghanapriya Yengkhom, Kunal Khemraj Nandgaonkar, Saikishore Ramanathan, Jan A. Schlegel, Meng Dong, Rahul A. Thorat, Rajiv Kumar, Subhash C. Yadav, Kumar Prabhash, Sharathchandra Arandkar

The paper identifies IGFBP5, 6, and 7 as key regulators of CAF heterogeneity in lung cancer, showing their role in promoting tumour growth and cisplatin resistance.

bioRxiv · Dec 7, 2025 · PreprintCancer Biology

Small fibre neuropathy in Fabry disease: a human-derived neuronal in vitro disease model

Thomas C. Klein, Julia Grüner, Maximilian Breyer, Jan A. Schlegel, Nicole Michelle Schottmann, Lukas Hofmann, Kevin Gauss, Rebecca Audrey Mease, Christoph Erbacher, Laura Finke, Alexandra M. Klein, Katharina Klug, Franziska Karl‐Schöller, Bettina Vignolo, Sebastian Reinhard, , Nurcan Üçeyler

This study creates a neuronal in vitro model of Fabry disease to investigate small fibre neuropathy mechanisms, finding Gb3 accumulation, altered ion channel function, and mitochondrial trafficking issues.

bioRxiv · Aug 9, 2023 · PreprintNeuroscience

A Multi-Parametric and High-Throughput Platform for Host-Virus Binding Screens

Jan A. Schlegel, Bartłomiej Porębski, Luca Andronico, Leo Hanke, Steven J. Edwards, Hjalmar Brismar, Ben Murrell, Gerald M. McInerney, Óscar Fernández-Capetillo, Erdinç Sezgin

This paper introduces a high-throughput platform for identifying host binding factors and antiviral drug targets by overcoming limitations in host plasma membrane complexity.

Nano Letters · Mar 9, 2023Peer-reviewedSynthetic Biology