Eric Brooks

Genetically engineered ESC-derived embryos reveal Vinculin-dependent force responses required for mammalian neural tube closure

The paper shows that Vinculin is essential for maintaining cell adhesion during cranial neural tube closure in mouse embryos under mechanical stress.

Canonical Wnt pathway modulation is required to correctly execute multiple independent cellular dynamic programs during cranial neural tube closure

This study shows that Wnt signaling must be modulated at different stages of cranial neural tube closure to regulate proliferation and apical constriction.

A single-cell atlas of spatial and temporal gene expression in the mouse cranial neural plate

The paper creates a single-cell RNA sequencing atlas of gene expression during mouse cranial neural tube closure, identifying spatially regulated genes and SHH-regulated programs in different brain regions.

Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure

This study identifies Sonic hedgehog signaling as a regulator of patterned apical constriction during cranial neural tube closure, revealing its role in preventing exencephaly.