Author

Heather L. Alcorn

Memorial Sloan Kettering Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Alyna KattiiD· 1 shared Andrew R Moorman· 1 shared Benjamin I. LeachiD· 1 shared Bhaswati BhattacharyaiD· 1 shared Brandon F Malone· 1 shared Dana Pe’eriD· 1 shared Danwei HuangfuiD· 1 shared David J. HugginsiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

Alyna KattiORCID

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3 papers

Recent·Most cited

A single-cell atlas of spatial and temporal gene expression in the mouse cranial neural plate

Eric Brooks, Andrew R Moorman, Bhaswati Bhattacharya, Ian S Prudhomme, Max Land, Heather L. Alcorn, Roshan Sharma, Dana Pe’er, Jennifer A. Zallen

The paper creates a single-cell RNA sequencing atlas of gene expression during mouse cranial neural tube closure, identifying spatially regulated genes and SHH-regulated programs in different brain regions.

eLife · Apr 7, 2025Peer-reviewedDevelopmental Biology

A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression

Jill Zimmerman, Brandon F Malone, Efrat Finkin-Groner, Shan Sun, Rui Liang, Miguel Foronda, Emma M. Schatoff, Elizabeth Granowsky, Sukanya Goswami, Alyna Katti, Benjamin I. Leach, Heather L. Alcorn, Tuomas Tammela, Yoshiyuki Fukase, Tanweer A. Khan, , Lukas E. Dow

The paper identifies a TNKS2-selective inhibitor that enables tumor-selective WNT suppression by exploiting 8p loss in cancer cells.

bioRxiv · Mar 4, 2025 · PreprintCancer Biology

A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation

Tingxu Chen, Heather L. Alcorn, Sujan Devbhandari, Dirk Remus, Elizabeth Lacy, Danwei Huangfu, Kathryn V. Anderson

This study identifies a Pold1 hypomorphic mutation in mice that causes reduced embryo size and morphogenetic defects during gastrulation, highlighting the need for coordinated growth and lineage specification.

Biology Open · Jul 25, 2022Peer-reviewedDevelopmental Biology