Jennifer A. Zallen

This study shows that Fimbrin-mediated actin crosslinking at tricellular junctions is essential for modulating actomyosin dynamics and reinforcing cell adhesion under tension during epithelial remodeling.

The paper shows that Vinculin is essential for maintaining cell adhesion during cranial neural tube closure in mouse embryos under mechanical stress.

The paper creates a single-cell RNA sequencing atlas of gene expression during mouse cranial neural tube closure, identifying spatially regulated genes and SHH-regulated programs in different brain regions.

This study identifies Sonic hedgehog signaling as a regulator of patterned apical constriction during cranial neural tube closure, revealing its role in preventing exencephaly.