Xiakun Chu

This study shows how phosphorylation and pocket-binding ligands regulate condensate organization in multidomain proteins like HDAC6 through distinct electrostatic and interaction mechanisms.

This study identifies post-adsorption alignment as a key bottleneck in PETase surface recognition and proposes a design strategy to improve productive binding.

This study reveals how DNA actively regulates condensin's safety-belt dynamics through multiscale simulations, showing DNA's role in stabilizing and modulating loop extrusion.

The paper develops a model to explain how chromatin compaction and structural plasticity are balanced by the valency of protein complexes.

This study quantifies chromosomal structural dynamics during embryogenesis, revealing allele-symmetric and asymmetric patterns in higher-order structures and geometrical compaction.

The paper uses polymer simulations to show that transcription factor condensates optimize enhancer-promoter communication through a 'golden mean' balance of clustering strength and genomic distance.

This study investigates how repulsive and attractive crowding environments affect TDP-43 condensates through distinct physical mechanisms and structural dynamics.

The paper develops chromatin models to study enhancer-promoter communication, finding that dynamic chromatin structures enhance transcriptional clustering and promote E-P interactions.

This study investigates how stability and flexibility balance in PET hydrolases affects catalytic activity, finding that a thermophilic variant shows enhanced performance through structural flexibility.