Molecular BiologyGenome biologyPeer-reviewed
Systematic comparison of dCas9-based DNA methylation epimodifiers over time indicates efficient on-target and widespread off-target effects
Majid Pahlevan Kakhki, Fatemeh Rangani, Ewoud Ewing…·M Jagodic
This study compares dCas9-based DNA methylation epimodifiers over time, showing efficient on-target effects but widespread off-target methylation and transcriptional changes.
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