This paper uses 6-base sequencing to analyze DNA modifications in cerebrospinal fluid cell-free DNA, providing insights into neurodegenerative biology for liquid biopsy applications.

bioRxiv · Sep 13, 2026 · PreprintNeuroscience

Systematic comparison of dCas9-based DNA methylation epimodifiers over time indicates efficient on-target and widespread off-target effects

Majid Pahlevan Kakhki, Fatemeh Rangani, Ewoud Ewing, Chiara Starvaggi Cucuzza, Galina Yurevna Zheleznyakova, Maria Kalomoiri, Lea Kenny, Anika Raghavan, Chandana Rao Prakash, Gabe van den Hoeven, T. S., Ruxandra Covacu, Ioanna Andreou, Maria Needhamsen, Lara Kular, M Jagodic

This study compares dCas9-based DNA methylation epimodifiers over time, showing efficient on-target effects but widespread off-target methylation and transcriptional changes.

Genome biology · Jan 31, 2026Peer-reviewedMolecular Biology

Anoctamin-2-specific T Cells Link Epstein-Barr Virus to Multiple Sclerosis

Olivia G. Thomas, Urszula Rykaczewska, Marina Galesic, Rianne T. M. van der Burgt, Nils Hallen, Filippo Ferro, Mattias Bronge, Zoe Marti, Yue Li, Alexandra Hill Rique, Jianing Lin, Aleksa Krstic, Alicja Gromadzka, Andras Levente Szonder, Chiara Sorini, , Tomas P Olsson

CD4+ T cells cross-reactive between Epstein-Barr virus EBNA1 and the central nervous system channel anoctamin-2 (ANO2) are elevated in multiple sclerosis and exacerbate experimental autoimmune encephalomyelitis in mice.

Cell · Jan 1, 2026Peer-reviewedImmunology✦ In-depth digest