Author

Andrew H. Coles

University of Massachusetts Chan Medical SchoolORCID 0000-0003-3218-6957Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Anastasia KhvorovaiD· 1 shared Anastasia P. Grigorenko· 1 shared Bruno M.D.C. GodinhoiD· 1 shared Chantal M. FergusoniD· 1 shared Dimas EcheverriaiD· 1 shared Evgeny Ivanovich RogaeviD· 1 shared Francesco Santarelli· 1 shared Jacquelyn SousaiD· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Anastasia KhvorovaORCID

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1 paper

Recent·Most cited

NeurosciencebioRxivPreprintJun 28, 2022

Silencing of ApoE with Divalent siRNAs Drives Activation of Immune Clearance Pathways and Improves Amyloid Pathology in Mouse Models of Alzheimer's Disease

Chantal M. Ferguson, Samuel R. Hildebrand, Bruno M.D.C. Godinho…·Anastasia Khvorova

This study shows that silencing ApoE in the brain with divalent siRNAs reduces amyloid plaques in Alzheimer's mice without affecting systemic cholesterol.

3 citations

mouseexperimental assay

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