Author

Chantal M. Ferguson

University of Massachusetts Chan Medical SchoolORCID 0000-0002-9442-1249Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3

Frequent Co-Authors

Anastasia KhvorovaiD· 3 shared Ashley SummersiD· 2 shared Bruno M.D.C. GodinhoiD· 2 shared Dimas EcheverriaiD· 2 shared Jillian BelgradiD· 2 shared Julianna E. BuchwaldiD· 2 shared Kathryn R. MonopoliiD· 2 shared Matthew R. HassleriD· 2 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Anastasia KhvorovaORCID

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Author profile →

3 papers

Recent·Most cited

RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice

Alexandra Weiss, James W. Gilbert, Iris Valeria Rivera Flores, Jillian Belgrad, Chantal M. Ferguson, Elif O. Dogan, Nicholas Wightman, Kit Mocarski, Dimas Echeverria, Ashley L. Harkins, Ashley Summers, Brianna Bramato, Nicholas McHugh, Raymond C. Furgal, Nozomi Yamada, , Anastasia Khvorova

The paper shows that silencing SOD1 with optimized di-siRNA extends survival and prevents disease progression in ALS mice.

Molecular Therapy · May 9, 2025Peer-reviewedNeuroscience

Di-valent siRNA Mediated Silencing of MSH3 Blocks Somatic Repeat Expansion in Mouse Models of Huntington's Disease

Daniel O’Reilly, Jillian Belgrad, Chantal M. Ferguson, Ashley Summers, Ellen Sapp, Cassandra A. McHugh, Ella W. Mathews, Adel Boudi, Julianna E. Buchwald, Socheata Ly, Dimas Moreno, Raymond C. Furgal, Eric Luu, Zachary Kennedy, Vignesh Narayan Hariharan, , Anastasia Khvorova

Silencing MSH3 in the CNS of two models of Huntington's disease using di-valent siRNA blocks disease-accelerating somatic expansion of CAG repeats.

Molecular Therapy · May 11, 2023Peer-reviewedMolecular Biology

Silencing of ApoE with Divalent siRNAs Drives Activation of Immune Clearance Pathways and Improves Amyloid Pathology in Mouse Models of Alzheimer's Disease

Chantal M. Ferguson, Samuel R. Hildebrand, Bruno M.D.C. Godinho, Julianna E. Buchwald, Dimas Echeverria, Andrew H. Coles, Anastasia P. Grigorenko, Lorenc Vanjielli, Jacquelyn Sousa, Nicholas McHugh, Matthew R. Hassler, Francesco Santarelli, Michael Thomas Heneka, Evgeny Ivanovich Rogaev, Anastasia Khvorova

This study shows that silencing ApoE in the brain with divalent siRNAs reduces amyloid plaques in Alzheimer's mice without affecting systemic cholesterol.

bioRxiv · Jun 28, 2022 · PreprintNeuroscience