Author

Jacquelyn Sousa

University of Massachusetts Chan Medical SchoolORCID 0009-0008-2592-9613Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Anastasia KhvorovaiD· 3 shared Dimas EcheverriaiD· 3 shared David CooperiD· 2 shared Nicholas McHughiD· 2 shared Samuel R. HildebrandiD· 2 shared Aamir MiriD· 1 shared Aditya Valji AnsodariaiD· 1 shared Alyxandr Srnka· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersNeuroscience

Anastasia KhvorovaORCID

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3 papers

Recent·Most cited

NeuroscienceNature CommunicationsPeer-reviewedJul 21, 2026

Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality for one year in an MECP2 duplication mouse model

Vignesh Narayan Hariharan, Ashley Summers, Amy E. Clipperton‐Allen…·Anastasia Khvorova

Therapeutic siRNAs provide safe and durable modulation of MECP2 for the treatment of mild and severe MECP2 Duplication Syndrome.

1 citation

mouseexperimental assay

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BiochemistrybioRxivPreprintMay 28, 2026

Fully Modified SpyCas9 Guide RNAs Enable Robust Genome Editing In Cells and In Vivo

Kim Anh Vu, Han Zhang, Nadia Amrani…·Jonathan K. Watts

The paper develops fully modified SpyCas9 guide RNAs that maintain or enhance genome editing efficacy in vitro and in vivo.

DOI 10.64898/2026.05.28.725424

humanCRISPR screen

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NeurosciencebioRxivPreprintJun 28, 2022

Silencing of ApoE with Divalent siRNAs Drives Activation of Immune Clearance Pathways and Improves Amyloid Pathology in Mouse Models of Alzheimer's Disease

Chantal M. Ferguson, Samuel R. Hildebrand, Bruno M.D.C. Godinho…·Anastasia Khvorova

This study shows that silencing ApoE in the brain with divalent siRNAs reduces amyloid plaques in Alzheimer's mice without affecting systemic cholesterol.

3 citations

mouseexperimental assay

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