Pro-inflammatory polarization and colorectal cancer modulate alternative and intronic polyadenylation in primary human macrophages
Joana Wilton, Filipa Lopes de Mendonça, Isabel Pereira‐Castro, Michael Tellier, Takayuki Nojima, Ângela M. Costa, Jaime Freitas, Shona Murphy, María José Oliveira, Nicholas J. Proudfoot, Alexandra Moreira
This study shows that pro-inflammatory polarization and CRC cell co-culture alter 3UTR-APA and IPA in primary human macrophages, with SRSF12 playing a key role.
Frontiers in Immunology · Jun 8, 2023Peer-reviewedMolecular Biology