Michael Tellier

Isoginkgetin and Madrasin are poor splicing inhibitors

This study shows that Madrasin and Isoginkgetin inhibit transcription before affecting splicing, suggesting they are not primary splicing inhibitors.

Inhibition of SF3B1 affects recruitment of P-TEFb to chromatin through multiple mechanisms

This study shows that SF3B1 inhibition disrupts P-TEFb recruitment to chromatin through multiple mechanisms involving nuclear export and degradation of splicing factors.

NELF coordinates Pol II transcription termination and DNA replication initiation

This study shows that NELF-C loss disrupts Pol II transcription termination and causes transcription-replication conflicts in colorectal cancer.

Pro-inflammatory polarization and colorectal cancer modulate alternative and intronic polyadenylation in primary human macrophages

This study shows that pro-inflammatory polarization and CRC cell co-culture alter 3UTR-APA and IPA in primary human macrophages, with SRSF12 playing a key role.

Cytoplasmic mRNA levels are regulated by a combination of chromatin retention and RNA stability.

The paper investigates how cytoplasmic mRNA levels are influenced by chromatin retention and RNA stability, finding that poor RNA processing leads to increased chromatin retention and shorter half-life.

CDK9 and PP2A regulate RNA polymerase II transcription termination and coupled RNA maturation.

This study shows CDK9 and PP2A regulate RNA polymerase II transcription termination and RNA maturation by modulating polyadenylation and splicing factors.

A series of constitutive expression vectors to accurately measure the rate of DNA transposition and correct for auto-inhibition

The paper develops constitutive expression vectors to measure DNA transposition rates and correct for auto-inhibition by testing Hsmar1 transposase variants.

SETMAR functions in illegitimate DNA recombination and non-homologous end joining

The paper investigates SETMAR's role in DNA integration and repair by analyzing cell lines with different SETMAR variants and finds that specific domains and activities are involved in these processes.

The RS Domain of Human CFIm68 Plays a Key Role in Selection Between Alternative Sites of Pre-mRNA Cleavage and Polyadenylation

This study shows that the RS domain of CFIm68 is critical for selecting between alternative polyadenylation sites in human cells.