Takayuki Nojima

This study shows SETD2 methyltransferase activity is crucial for correct transcription initiation and termination, with distinct effects on gene classes in RCC.

This study directly sequences pre-mRNA to resolve transcription and processing at single-molecule resolution, revealing delayed splicing and m6A methylation preceding splicing.

The paper shows mammalian RNA polymerase II can terminate transcription at T-tracts, a mechanism also seen in prokaryotes and RNAPIII, and demonstrates this occurs genome-wide in promoter-proximal regions.

This study shows that NELF-C loss disrupts Pol II transcription termination and causes transcription-replication conflicts in colorectal cancer.

This study shows that pro-inflammatory polarization and CRC cell co-culture alter 3UTR-APA and IPA in primary human macrophages, with SRSF12 playing a key role.

This study shows CDK9 and PP2A regulate RNA polymerase II transcription termination and RNA maturation by modulating polyadenylation and splicing factors.

The paper introduces POINT technology to study co-transcriptional RNA processing, revealing insights into splicing kinetics, Xrn2 exonuclease specificity, and transcript termination mechanisms.

This study shows that enhancers primarily regulate gene expression by promoting transcription initiation rather than by affecting RNA polymerase II pausing.

This study shows PCF11 is critical for vertebrate development by promoting transcription termination and preventing transcriptional interference.