Nicholas J. Proudfoot

This study identifies MBLAC2 as a nucleolar nuclease essential for co-transcriptional rRNA processing and global transcriptional output.

The paper shows mammalian RNA polymerase II can terminate transcription at T-tracts, a mechanism also seen in prokaryotes and RNAPIII, and demonstrates this occurs genome-wide in promoter-proximal regions.

This study shows that pro-inflammatory polarization and CRC cell co-culture alter 3UTR-APA and IPA in primary human macrophages, with SRSF12 playing a key role.

The paper introduces POINT technology to study co-transcriptional RNA processing, revealing insights into splicing kinetics, Xrn2 exonuclease specificity, and transcript termination mechanisms.

This study shows that enhancers primarily regulate gene expression by promoting transcription initiation rather than by affecting RNA polymerase II pausing.

This study shows PCF11 is critical for vertebrate development by promoting transcription termination and preventing transcriptional interference.

The paper shows that PrimPol-mediated repriming limits R-loop formation during S phase, preventing replication blocks at susceptible sequences.