NeurosciencebioRxivPreprint
ALS-Associated TDP-43 Dysfunction Compromises UPF1-Dependent mRNA Metabolism Pathways Including Alternative Polyadenylation and 3'UTR Length
Francesco Alessandrini, Matthew Wright, Tatsuaki Kurosaki…·Evangelos Kiskinis
The paper identifies UPF1 targets in motor neurons and shows TDP-43 dysfunction disrupts UPF1-mediated mRNA surveillance and 3'UTR regulation in ALS.
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