ALS-Associated TDP-43 Dysfunction Compromises UPF1-Dependent mRNA Metabolism Pathways Including Alternative Polyadenylation and 3'UTR Length
Francesco Alessandrini, Matthew Wright, Tatsuaki Kurosaki, Lynne E. Maquat, Evangelos Kiskinis
The paper identifies UPF1 targets in motor neurons and shows TDP-43 dysfunction disrupts UPF1-mediated mRNA surveillance and 3'UTR regulation in ALS.
bioRxiv · Jan 31, 2024 · PreprintNeuroscience