Matthew Wright

This study shows that APOL1 G1 and G2 risk alleles affect diet-induced obesity severity differently in male and female transgenic mice.

This study shows G1 and G2 APOL1 variants increase macrophage inflammation and lipid accumulation via the polyamine pathway, which can be inhibited by DFMO.

The paper shows that the circadian clock in spinal cord cholinergic neurons affects RNA metabolism and contributes to ALS disease phenotypes through rhythmic gene expression and alternative splicing.

The paper identifies context-dependent interactors of TDP-43 that regulate its dysfunction in ALS/FTLD using proximity labeling, mass spectrometry, and snRNA-seq integration.

This study identifies DNAJC7 as a mediator of neuroprotection in ALS by modulating HSF1 activity and shows that HSF1 expression can rescue proteotoxic stress in mutant DNAJC7 neurons.

The paper identifies UPF1 targets in motor neurons and shows TDP-43 dysfunction disrupts UPF1-mediated mRNA surveillance and 3'UTR regulation in ALS.