Author
Hospital for Sick ChildrenORCID 0000-0003-3233-9204Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Mila Mirceta, Monika H.M. Schmidt, Natalie Shum…·Christopher E. Pearson
This paper shows C9orf72 expansions create a folate-sensitive fragile site FRA9A, leading to chromosomal instability and immune responses in patient cells and mice.
Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic…·Christopher E. Pearson
The paper investigates the roles of canonical and alternative RPA in CAG repeat diseases, finding that Alt-RPA antagonizes RPA's suppression of CAG expansions, contributing to disease pathogenesis.
Amit Laxmikant Deshmukh, Marie‐Christine Caron, Mohiuddin Mohiuddin…·Christopher E. Pearson
The paper shows FAN1 nuclease processes and pauses on slipped-DNA repeats, reducing repeat expansions and delaying disease onset.