Author

Natalie Shum

Hospital for Sick Children

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 1

Frequent Co-Authors

Christopher E. PearsoniD· 2 shared Mahreen KhaniD· 2 shared Mohiuddin MohiuddiniD· 2 shared Peixiang WangiD· 2 shared Ryan K. C. YueniD· 2 shared Stella LanniiD· 2 shared Agessandro AbrahãoiD· 1 shared Aisha FaruquiiD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersGenetics

Christopher E. PearsonORCID

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2 papers

Recent·Most cited

C9orf72 expansion creates the unstable folate-sensitive fragile site FRA9A

Mila Mirceta, Monika H.M. Schmidt, Natalie Shum, Tanya K. Prasolava, Bryanna Meikle, Stella Lanni, Mohiuddin Mohiuddin, Paul M. McKeever, Ming Zhang, Minggao Liang, Ilse van der Werf, Stefaan Scheers, Patrick A. Dion, Peixiang Wang, Michael D. Wilson, , Christopher E. Pearson

This paper shows C9orf72 expansions create a folate-sensitive fragile site FRA9A, leading to chromosomal instability and immune responses in patient cells and mice.

bioRxiv · Oct 26, 2024 · PreprintGenetics

FAN1 nuclease processes and pauses on disease-associated slipped-DNA repeats: Mechanism against repeat expansions

Amit Laxmikant Deshmukh, Marie‐Christine Caron, Mohiuddin Mohiuddin, Stella Lanni, Gagan B. Panigrahi, Mahreen Khan, Worrawat Engchuan, Natalie Shum, Aisha Faruqui, Peixiang Wang, Ryan K. C. Yuen, Masayuki Nakamori, Kazuhiko Nakatani, Jean‐Yves Masson, Christopher E. Pearson

The paper shows FAN1 nuclease processes and pauses on slipped-DNA repeats, reducing repeat expansions and delaying disease onset.

Cell Reports · Dec 1, 2021Peer-reviewedGenetics